Abstract A77: Validation of the EORTC QLQ-OV28 instrument for the assessment of quality of life in women with ovarian carcinoma in Mexico

Objective: Health-related quality of life (HRQL) is an important outcome measurement in Oncology. Our aim was to validate the Mexican-Spanish version of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-OV28 questionnaire to assess HRQL in patients with Ovarian cancer (OC). Patients and Methods: The QLQ-C30 and QLQ-OV28 instruments were applied to Mexican patients with OC at a cancer referral centre. Reliability and validity tests were performed, and test-retest analysis was carried out in a subgroup of patients. Results: Two hundred fifty-two women were included in this cohort. Questionnaire compliance rates were high and the instrument was well accepted; internal consistency tests demonstrated good convergent and divergent validity. Cronbach's α; coefficients of 8 of 9 multi-item scales of the QLQ-C30 and of 6 of 8 scales of the QLQ-OV28 instruments were >0.7 (range, 0.22 to 0.89). Scales of the QLQ-C30 and QLQ-OV28 instruments distinguished among clinically distinct groups of patients; some were highly sensitive to change over time after the use of induction chemotherapy, and some were associated to overall survival. Conclusion: The Mexican-Spanish version of the QLQ-OV28 questionnaire is reliable and valid for the assessment of HRQL in patients with OC and can be broadly used in clinical trials. Citation Format: Dolores Gallardo-Rincon, Wendy Munoz-Montano, David Cantu de Leon, Jaime Coronel-Martinez, Flavia Morales, Luis F. Onate-Ocana. Validation of the EORTC QLQ-OV28 instrument for the assessment of quality of life in women with ovarian carcinoma in Mexico. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr A77.