Abstract C071: From promise to progress: Utilizing the All of Us  dataset to advance cancer disparities research

As the world’s largest and most diverse dataset of its kind, the All of Us Research Program within the National Institutes of Health is a national effort that is building the largest, most diverse health information database that researchers can use to study how different genetic, lifestyle, and environmental factors impact health and disease. All of Us is built in partnership with participants spanning different ages, races, ethnicities, and regions of the country, including 45% who self-identify as racial and ethnic minorities and 75% from communities underrepresented in biomedical research (UBR). In addition to contributing to health research, participants are active partners of the program through participation in the program’s governance and ongoing engagement within the Engagement Ecosystem ‒ a network of national partners with deep connections to communities. These partners work collaboratively to reach specific populations by raising awareness about the program among racial/ethnic minority populations and historically underrepresented communities, such as LGBGTQIA+, disability communities, and rural and older adults, in an effort to complement and enhance existing outreach and engagement efforts.As of April 2023, the program has data from 413,450+ participants, containing the largest set of whole genome sequences (WGS) widely available for research with over 312,900 genotyping arrays, 245,350 WGS, and 1,000 long-read sequences available to registered researchers. To ensure value is returned, participants may consent to receiving a personalized DNA report with information on genetic ancestry, traits, pharmacogenetics, and a hereditary disease risk report on the ACMG 59 “medically actionable” genes, with 20 genes related to some type of cancer. The most common conditions available include cancer, cardiovascular disease, hypertension, mental health, and diabetes. There is also electronic health record (EHR) data from more than 287,000 participants inclusive of demographics, health care visits, diagnoses, and medications data, with over 50,700 diagnosed with at least one type of cancer. As many cancer disparities are driven by the interaction of biological and social factors, All of Us provides an opportunity for researchers to explore data on lifestyle factors, social determinants of health, 3-digit zip codes, neighborhood, social life and exposures, including potential indications of allostatic load and inflammatory markers associated with stress and