Abstract 3827: Schinus terebinthifolius extracts impair migration of BT549 triple negative breast cancer cells in vitro

Abstract 3827: Schinus terebinthifolius extracts impair migration of BT549 triple negative breast cancer cells in vitro

Bark extracts, derived from the Brazilian peppertree (Schinus terebinthifolius) were tested on BT549 triple negative breast cancer cells, a model system for invasive, metastatic cancers. Crude extracts, prepared with a 50% ethanol-50% water solvent, were investigated for cytotoxicity and effects on...

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Veröffentlicht in:Cancer research (Chicago, Ill.) Ill.), 2023-04, Vol.83 (7_Supplement), p.3827-3827
Hauptverfasser: Tapanes-Castillo, Alexis, Santi, Mariacira Di, Sousa, Abel, Brown, Jonathan M., Rodriguez, Paola M. Gonzalez, Leal, Thiago P., Saladrigas, Leticia, Trokhymchuk, Vadym, Chumpitaz, Leonardo M. Soto, Peterson, Andrea, Gutierrez, Susana, Petit, Rolando J., Planchart, Carlos, Corro, Christian Del, Ramos, Daniela A., Nazaire, Valeria, Mondesire, Sean, Pina, Maria
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Sprache:eng
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Zusammenfassung:Bark extracts, derived from the Brazilian peppertree (Schinus terebinthifolius) were tested on BT549 triple negative breast cancer cells, a model system for invasive, metastatic cancers. Crude extracts, prepared with a 50% ethanol-50% water solvent, were investigated for cytotoxicity and effects on cell migration in vitro. Extract-treated cells exhibited statistically significant slower migration velocities than untreated control cells. Crude bark extracts, screened at a concentration of 3.15mg/mL in five independent experiments, produced an approximate 80% decrease in average migration velocity (p
ISSN:1538-7445
1538-7445
DOI:10.1158/1538-7445.AM2023-3827