Abstract 2970: Multiple new susceptibility loci identified in genome-wide association study of Ewing sarcoma
Ewing sarcoma (EWS) is a rare pediatric tumor predominantly occurring in children of European ancestry and is characterized by the pathognomonic EWSR1-FLI1 fusion oncogene. To identify germline susceptibility loci associated with EWS risk, we performed a genome-wide association study (GWAS) meta-ana...
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Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2018-07, Vol.78 (13_Supplement), p.2970-2970 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Ewing sarcoma (EWS) is a rare pediatric tumor predominantly occurring in children of European ancestry and is characterized by the pathognomonic EWSR1-FLI1 fusion oncogene. To identify germline susceptibility loci associated with EWS risk, we performed a genome-wide association study (GWAS) meta-analysis of 749 EWS cases and 1,378 unaffected individuals of European ancestry from sample collections within the Institut Curie, National Cancer Institute and the Childhood Cancer Survivor Study. Our study replicated previously reported susceptibility loci at 1p36.22, 10q21.3 and 15q15.1 as well as identified novel loci at 6p25.1, 8q24.23, 20p11.22 and 20p11.23 (P-values |
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ISSN: | 0008-5472 1538-7445 |
DOI: | 10.1158/1538-7445.AM2018-2970 |