Abstract 5632: Thyroid carcinoma in The Sudan

Introduction: Goiter is endemic in Sudan and thyroidectomy is a daily practice in most surgical lists across the country. The most common indications are cosmoses and pressure with respiratory choking. In 10% of cases a surprise histopathology on cancer is reported . This study aims to report on thyroid carcinoma on patients presenting to the surgical department in Khartoum Teaching Hospital. Methods: This study is an overview on pattern, clinical presentation a management of thyroid carcinoma in Khartoum during the period 2007 - 2014. Thyroidectomy was the standard procedure when feasible and postoperative radio iodine given. External radiotherapy was given in aggressive anaplastic carcinoma. Results: 166 patients with thyroid cancer were studied. The mean age was 51 +/-SD 17yrs and the age range between 15 - 85 years. Male to female ratio was 1.0:2.4. Clinical presentation was a goiter that was showing a recent rapidly growth with either respiratory choking, pain and dysphagia. Follicular carcinoma was 43%,papillary 27%, anaplastic 10% 2%medullary. Sarcoma and lymphoma 5% and missing data in 13%. Six per cent of patients presented with lung and bone metastasis. 20 patients had long standing goiter before development of cancer. Different types of total thyroidectomy done in 81%, no surgery in 7% and missing data in 12%. 18 patients needed postoperative tracheostomy, 7 developed permanent hypocalcaemia, 15 recurrent nerve palsy and a 30 days mortality was 10% and all were anaplastic carcinoma where recurrence occurred within weeks following thyroidectomy or dublking in most cases. Conclusion: Patients with thyroid cancer presents late. The dominance of follicular type indicates the significance of underlying endemic goiter in its etiology. Anaplastic is very aggressive and lethal outcome. Citation Format: Mohamed ElMakki Ahmed. Thyroid carcinoma in The Sudan [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5632. doi:10.1158/1538-7445.AM2017-5632