Abstract 5605: Frequencies of HLA-Class I and II alleles between German patients with renal cell carcinoma and healthy controls can be different

The human leukocyte antigen (HLA) system is a major part of the human immune system and has an impact on tumor initiation, tumor progression and immunosurveillance. Renal cell carcinoma tumors are considered to be immunogenic. Therefore, we studied the allele frequencies of four gene loci (HLA-A, -B, -C and HLA-DR) in a cohort of 106 German renal cell carcinoma (RCC) patients and in 201 healthy controls. HLA-A-C were determined using serological methods, whereas HLA-C12, C14, C16, C18 and HLA-DR were characterized through the use of standard molecular biological methods. The presence of HLA-A and HLA-B alleles did not differ significantly between RCC patients and healthy controls. However, the occurrence of the HLA-C*12 allele was significantly increased in German RCC patients compared with healthy controls (P < 0.005; RR=2.3; Fisher’s exact test), whereas the occurrence of the HLA-DRB1*04 allele was significantly reduced in RCC patients compared with healthy controls (P < 0.05; RR=0.7; Fisher’s exact test). But the presence of allele HLA-C*12 was not significantly associated with 10 years overall survival. We suggest that the frequency of HLA alleles can affect development of RCC and could add knowledge as predictive marker for future immunotherapies. Citation Format: Steffen Göbel, Astrid Kehlen, Karen Bluemke, Wolfgang Altermann, Gerald Schlaf, Kersten Fischer, Paolo Fornara, Bernd Wullich, Sven Wach, Helge W. Taubert. Frequencies of HLA-Class I and II alleles between German patients with renal cell carcinoma and healthy controls can be different [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5605. doi:10.1158/1538-7445.AM2017-5605