Abstract 2553: High-density array-CGH with targeted NGS unmask multiple non-contiguous minute deletions on chromosome 3p21 in mesothelioma

Abstract 2553: High-density array-CGH with targeted NGS unmask multiple non-contiguous minute deletions on chromosome 3p21 in mesothelioma

We used a custom-made comparative genomic hybridization-array (aCGH; average probe interval 254 bp) to screen 33 malignant mesothelioma (MM) biopsies for somatic copy number loss throughout the 3p21 region (10.7 Mb) that harbors 251 genes, including BRCA1-associated protein 1 (BAP1), the most common...

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Veröffentlicht in:Cancer research (Chicago, Ill.) Ill.), 2017-07, Vol.77 (13_Supplement), p.2553-2553
Hauptverfasser: Carbone, Michele, Yoshikawa, Yoshie, Emi, Mitsuru, Hashimoto-Tamaoki, Tomoko, Ohmuraya, Masaki, Sato, Ayuko, Tsujimura, Tohru, Hasegawa, Seiki, Nakano, Takashi, Nasu, Masaki, Pastorino, Sandra, Szymiczek, Agata, Bononi, Angela, Pass, Harvey I., Yang, Haining
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Sprache:eng
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Zusammenfassung:We used a custom-made comparative genomic hybridization-array (aCGH; average probe interval 254 bp) to screen 33 malignant mesothelioma (MM) biopsies for somatic copy number loss throughout the 3p21 region (10.7 Mb) that harbors 251 genes, including BRCA1-associated protein 1 (BAP1), the most commonly mutated gene in MM. We identified frequent minute biallelic deletions (
ISSN:0008-5472
1538-7445
DOI:10.1158/1538-7445.AM2017-2553