Abstract 5550: Corilagin, an anti-tumor herb medicine, sensitizes paclitaxel and carboplatin by primarily inhibiting glycolysis pathways in epithelial ovarian cancer

We have identified that Corilagin is a major anti-tumor active component extracted from a well-known hepatoprotective and antiviral medicinal herb, Phyllanthus niruri L. Our previous works found that Corilagin inhibited the growth of ovarian cancer cells via TGF-β/AKT/ERK signaling pathways. Recently, we have examined if Corilagin could enhance the sensitivity of chemotherapy in ovarian cancer cells. Different concentration of Corilagin were used in combination assays with paclitaxel and carboplatin in ovarian cancer cell lines SKOv3ip, Hey and HO-8910PM. Corilagin distinctly increased inhibition effects of paclitaxel and carboplatin (p