Abstract 4645: Decursin, a coumarin compound, inhibits the growth of human hepatoma cells involving cell cycle arrest, apoptosis, and autophagy

Although recent advances have been made for the treatment of liver cancer, it still remains the sixth most diagnosed cancer worldwide and second most cause of mortality related to cancer. Decursin, a naturally occurring coumarin compound isolated from Angelica gigas Nakai is known for its hepatoprotective activity. For the first time we show that decursin has strong cytotoxic and growth inhibitory effects against liver cancer cells. Decursin (1-25 μM) resulted in a dose-dependent inhibition of Hep3B cell proliferation by upto 65-85% (p