Abstract 2870: A novel metastasis-associating LincRNA destabilizes tumor-suppressor mRNAs through cooperative action with NF90/ILF3 binding

Background: Recent genome-wide profiling by sequencing and distinctive chromatin signatures has identified thousands of long intergenic non-coding RNA (lincRNA) species (>200 nt). LincRNAs are emerging as important regulators of gene expression. While altered expressions of lincRNAs have been observed to play an important role in tumorigenesis, their roles in breast cancer (BCa) progression and metastasis are still poorly understood. Experimental designs and results: To discover novel BCa-associated lincRNA transcripts, we have employed a high-density SNP array based approach, in which we specifically probed the transcripts in the human intergenic region to globally explore lincRNA genes that are aberrantly expressed in BCa. We found 38 lincRNA transcripts that were dysregulated in tumors (P