Abstract 5242: miR-10b functions as a novel tumor suppressor in uterine leiomyosarcoma by promoting overexpression of SDC1

MicroRNAs (miRNAs) are endogenous RNA transcripts that play a critical role in regulating pleuripotency and differentiation. Altered miRNA expression is a well-established feature of nearly all human cancers. However, the mechanisms by which dysregulated miRNA expression promote tumorigenesis remain poorly understood.To evaluate the role of miRNAs in uterine leiomyosarcoma (uLMS), we profiled patterns of small RNA expression in matched specimens of healthy myometrium (n=34), uterine leiomyomas (n=34) and uterine leiomyosarcoma (n=12) using Next Generation Sequencing (NGS). After quantile normalization, patterns of mature miRNA transcripts were compared. We found that 37 individual miRNAs were differentially expressed >2-fold (p8-fold, p2-fold when uLMS were compared to myometrium (p