Abstract 4871: Obesity-mediated regulation of HGF/c-Met and reduced basal-like breast cancer latency in parous mice

Abstract 4871: Obesity-mediated regulation of HGF/c-Met and reduced basal-like breast cancer latency in parous mice

Background: Epidemiologic and experimental data have shown that a full term pregnancy reduces breast cancer risk. While a full term pregnancy reduces risk for estrogen receptor positive (ER+) and luminal breast cancers, parity is associated with increased risk of basal-like breast cancer (BBC) subty...

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Veröffentlicht in:Cancer research (Chicago, Ill.) Ill.), 2014-10, Vol.74 (19_Supplement), p.4871-4871
Hauptverfasser: Sundaram, Sneha, Freemerman, Alex J., Kirk, Erin L., Galanko, Joseph A., McNaughton, Kirk K., Bendt, Katharine M., Darr, David B., Troester, Melissa A., Makowski, Liza
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Sprache:eng
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Zusammenfassung:Background: Epidemiologic and experimental data have shown that a full term pregnancy reduces breast cancer risk. While a full term pregnancy reduces risk for estrogen receptor positive (ER+) and luminal breast cancers, parity is associated with increased risk of basal-like breast cancer (BBC) subtype. BBC represents
ISSN:0008-5472
1538-7445
DOI:10.1158/1538-7445.AM2014-4871