Abstract 3013: Elucidating the functional role of microfibril-associated glycoprotein-2 (MAGP-2) in human ovarian cancer

Epithelial ovarian cancer, is the most fatal gynecologic cancer, resulting in approximately 15,000 deaths annually in the US. Our understanding of molecular events relating to the patient survival and overall prognosis is not clear. Using transcriptional profiling technology combined with Cox regression analysis in microdissected serous ovarian cancers, we have identified microfibril-associated glycoprotein 2 (MAGP-2) as a strong prognostic factor toward poor patient outcome. Ectopic overexpression of MAGP-2 was employed to evaluate its functional role in ovarian cancer. MAGP-2 overexpression increased cell migration and resistance to cisplatin in vitro. Moreover, the conditioned medium from MAGP-2 overexpression cells promoted endothelial cell motility. In an orthotopic model using luciferase labeled ovarian cancer cells, MAGP-2 overexpression increased the intraperitoneal tumor growth. In addition, the tumor with high MAGP-2 expression showed increased microvessel density. Our results suggest MAGP2 positively modulates the ovarian cancer tumorigenecity and angiogenesis, which may subsequently lead to poor patient survival. Citation Format: Young-Jeong Na, Vinod Vathipadiekal, Wei Wei, Tim Kwok, Michael Birrer. Elucidating the functional role of microfibril-associated glycoprotein-2 (MAGP-2) in human ovarian cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3013. doi:10.1158/1538-7445.AM2013-3013