Abstract 4511: The effect of obesity-related adipokines at diagnosis on breast cancer survival

Background: Although a number of experimental studies have suggested the effect of obesity-related adipokines in breast cancer progression, limited numbers of epidemiological studies have examined the relationship between the adipokines and breast cancer survival. Patients and methods: Preoperative serum levels of obesity-related adipokines including leptin, adiponectine and hepatocyte growth factor (HGF) were measured in 370 breast cancer patients recruited between 2004 and 2007. We examined the association between those adipokines and disease-free survival (DFS) using Cox proportional hazard regression model. Results: There was no difference in age distribution, menopausal status, BMI, PR status, tumor size, and lymph node status between survivor and recurrence or death subjects. On the other hand, the TNM stage, ER status and histological grade were observed the association with breast cancer survival. Elevated adiponectin were associated with reduced DFS of breast cancer (P for trend = 0.047) with adjustment for age, ER/PR status, histological grade, nuclear grade and TNM stage among patient with less than 4 year survival time. There was no association of leptin and HGF with the breast cancer survival. Conclusions: Our study suggests that the elevated levels of adiponectine at diagnosis are associated with breast cancer survival, but the leptin and HGF level in blood not associated. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4511. doi:1538-7445.AM2012-4511