Abstract 1960: Nanosponges as suitable platforms for targeted chemotherapy

We will report on the treatment efficacy of a degradable nanosponge drug delivery system. Degradable targeted nanosponges have been developed that are tailored in size and cross-linking density as supramolecular 3-D nano-networks. The organic polyester backbone can be functionalized in convenient ‘click’ chemistries with targeting peptides, dyes and cell penetrating units with particles that are fully soluble in organic solvents but retain their cross-linked architecture like a macromolecule. Furthermore, we found that the tailoring of the cross-linking density of the particles are correlated to the degradation and release properties of the particles to govern a fast, medium and slow linear release of the encapsulated drugs. Drugs can be encapsulated after the nanoparticle is formed and specifically hydrophobic drugs, for example chemotherapeutics, can be encapsulated with high efficiencies. The encapsulation into particle was found to be advantageous towards the solubility of the drug itself and resulted in vivo studies that showed a 3-5 time higher efficacy of the drug in targeted tumor regression studies. Similar efficacies are observed in glioma and lung cancer. We will report on novel combination therapies and efforts towards the delivery of a broad range of therapeutics in non-small lung cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1960. doi:1538-7445.AM2012-1960