Abstract 1830: Factors associated with fatigue, sleep dysfunction, and joint symptoms in breast cancer survivors

Background: Fatigue, sleep dysfunction, and joint symptoms may negatively impact quality of life in breast cancer survivors (BCS). Prior studies examining associated factors have yielded inconsistent results. Objective: Determine demographic, medical, exercise-related, body composition and serum inflammatory factors associated with fatigue, sleep dysfunction, and/or joint symptoms in BCS. Methods: Post-hoc analysis of baseline data completed by 37 BCS enrolled in a pre/post intervention study or randomized trial. Self administered survey assessed demographics, medical variables, self-efficacy (i.e., confidence in ability to exercise), fatigue (FSI), sleep dysfunction (PSQI), and joint symptoms (WOMAC). Sleep was also objectively assessed with an accelerometer. Body composition was assessed by body mass index (BMI), waist-to-hip ratio (WHR), and percent body fat (bioelectrical impedance). Cardio respiratory fitness was assessed with sub maximal treadmill test and muscle strength with back/leg extensor dynamometer. Multiplex high sensitivity assay or ELISA was performed on fasting serum samples to determine levels of cytokines or other markers related to body composition. Due to the skewed nature of several variables, Spearman correlations (r) were performed. A significant p value was set at