Ethnic and geographical variability of breast cancer at the Osh region in Kyrgyzstan

Abstract #6096 Background. To study age, regional and ethnic breast cancer incidence at the Osh region of the Kyrgyz republic. Material and methods. Calculated the incidence of breast cancer between 1995 and 2005. There were registered 386 females with a new diagnoses of breast cancer. Collected dates from histological or cytological findings, and deaths certificates. Estimated population relative risk (RR) for breast cancer in the urban and rural areas. The population figures and cancer incidence rates for this report were provided in for age groups (0-4, 5-9, 75 >) and ethnic groups. Counted crude, age-standardized rates (ASR) per 100 000. The classification scheme used by ICD-10. Results. Only one patient (0.3%) has T1N0M0 stage of disease. Stage distribution: II – 107 (28%), III – 233 (60.9%), IV – 41 (10.8%). ASR annual incidence in breast cancer was 6.51 (1995), 8.54 (2000), and 12.53 in 2005. Cancer incidence was significantly higher at the Osh city (17.87). Average rate was registered at the Karasu (8.06), Uzgen (7.09), Aravan (6.09), Naukat (6.4), and Karakuldga (6.14) regions. Low incidence was registered at the Alay (2.12), and Chonalay (4.55) areas. High incidence of breast cancer was registered in the urban (ASR-16.6) compared with rural regions with ASR 5.16 (RR=3.21, CI 95%- 2.7; 3.8) Relative risk for breast cancer was significantly higher in the Slavic ethnic groups (Ukraines and Russians with ASR of 66.4 cases per 100 000) compared with 3.75 for Kyrgyzs (RR=17.7), or 7.16 for Uzbek females (RR=9.27). High incidence rate of breast cancer was registered in female with the richest socioeconomic status (more than 80% cases), compared with poorest status. Also high incidence was demonstrated in female in reproductive time of live (53.1%), dysmenorrheal status (78.8%), and aborts in anamnesis (65.4%). Discussion. Breast cancer incidence at the Osh region of Kyrgyzstan is very low and similar to those reported from some developing countries. These analyses suggest that relative high risk in Russians compared with native ethnic groups may be related to some reproductive characteristics, number of child, socioeconomic status, and other. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 6096.