Six‐ and Seven‐Membered 1‐Oxa‐4‐Aza‐2‐Silacyclanes as PossibleCorrectors of Adaptational Mechanisms

The biological activity of eight 1‐oxa‐4‐aza‐2‐silacyclanes with the OSiCH 2 N fragment including 6‐membered 2‐sila‐5‐morpholinones ( 1–3 ) and 4‐acyl‐2‐silamorpholines ( 4–6 )and previously unknown 7‐membered derivatives of salicylic acid ( 7 , 8 ) was studied. Compounds 1 and 3–6 show the certain antihypoxic action. Compounds 2 (40 mg/kg), 4 (20 mg/kg), 6 (40 mg/kg), 7 (20 mg/kg) and 8 (40 mg/kg) reduce the physical serviceability of intact animals. Compound 1 (20 mg/kg) influences the physical serviceability in a moderate‐positive way on the background of chlorophos‐poisoning. Compounds 5–8 displayed protective properties against chlorophos‐poisoning at the LD 50 dose and compounds 2 , 4 , 5 , 7 at the LD 100 dose. Influence of compounds 1 and 2 on the emotional‐research behavior of mice was studied.