Hypolipidemic Activity of Amine‐Borane Aducts of Cyclohexylamineand Toluidine in Rodents

The amine‐borane adducts of cyclohexylamine and toluidine were observed to be potent hypolipidemic agents in mice, I.P. and rats orally at 8 mg/kg/day lowering both serum cholesterol and triglyceride levels after 14‐16 days. These compounds were able to lower tissue lipids including the cholesterol content of the aorta wall. The agents successfully lower VLDL‐ and LDL‐cholesterol content while elevating HDL‐cholesterol content significantly. The agents also modulate lipid regulatory enzyme activities in a manner to reduce liver lipid levels. These studies demonstrate that the nitrogen atom does not have to be apart of the aromatic ring as in heterocyclic‐amine borane to afford good hypolipidemic activity in rodents.