18 F‐FDG MicroPET and MRI Targeting Breast Cancer Mouse Model with Designed Synthesis Nanoparticles

The first aim of this study was the development of real‐time, quantitative, and noninvasive visual observation that necessitates different noninvasive multimodal imaging methods. Second, the design of a high‐sensitivity imaging free‐ligand green chemistry nanoprobe is a critical diagnosis of breast cancer mouse models. The gadolinium‐based nanoparticles as box‐Behnken design (BBD) experiment are synthesized. A small biomolecule L‐glutamine is attached to its surface nanoparticles as a template. Large surface‐area‐to‐volume ratios of nanoparticles enhance the capacity for interactions with biomolecules and present more sites for conjugation. G. 2‐Deoxy‐2[ 18 F]fluoro‐D‐glucose ([ 18 F]F‐FDG) is a quantitative and sensitive tracking instrument in Positron Emission Tomography (PET), also applicable for the in vivo and in vitro characterization of L‐glutamine SiGdNPs. Optical imaging was done for 4T1 breast cancer tumor‐induced mice. 18 F‐NP uptake values were significantly higher in primary breast cancer and brain tumors than [ 18 F]F‐FDG in PET at 30 min, injected (20 μ l/g) via the tail vein with about 300 μ Ci of 18 F‐FDG loading. After 15 min of the administration of injection (26 μ l/g), the first passed the lung intravenously without any injury to the lung showing promising T1‐T2 MRI contrast properties. We receive these by application of a variety of imaging modalities, especially microPET and MRI.