Thio-β-D-glucosides : Synthesis and Evaluation as Glycosidase Inhibitors and Activators

Thio-β-D-glucosides : Synthesis and Evaluation as Glycosidase Inhibitors and Activators

Structurally simple 1-thio-β-D-glucopyranosides were synthesized and tested as potential inhibitors toward several fungal glycosidases from Aspergillus oryzae and Penicillium canescens. Significant selective inhibition was observed for α- and β-glucosidases, while a weak to moderate activation for α...

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Veröffentlicht in:International Journal of Carbohydrate Chemistry 2014-12, Vol.2014 (2014), p.1-8
Hauptverfasser: Samoshin, Andrey V., Dotsenko, Irina A., Samoshina, Nataliya M., Franz, Andreas H., Samoshin, Vyacheslav V.
Format: Artikel
Sprache:eng
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Zusammenfassung:Structurally simple 1-thio-β-D-glucopyranosides were synthesized and tested as potential inhibitors toward several fungal glycosidases from Aspergillus oryzae and Penicillium canescens. Significant selective inhibition was observed for α- and β-glucosidases, while a weak to moderate activation for α- and β-galactosidases.
ISSN:1687-9341
1687-935X
DOI:10.1155/2014/941059