Syntheses and Antibacterial Studies of Some 1‐Phenyl‐3‐(4‐(2‐ethanoloxy) phenyl)‐5‐aryl‐1 H ‐pyrazoles

A series of 1‐phenyl‐3‐(4‐(2‐ethanoloxy) phenyl)‐5‐aryl‐1 H ‐pyrazoles were synthesized from chalcones, that is, 3‐aryl‐1‐(4‐hydroxyphenyl) prop‐2‐en‐1‐ones and studied for their in vitro antibacterial activity. Chalcones 1 on reaction with phenyl hydrazine in the presence of acetic acid and few drops of hydrochloric acid yielded the corresponding 1‐phenyl‐3‐(4‐hydroxyphenyl)‐5‐aryl‐1 H ‐pyrazoles 2 which on further reaction with 2‐chloroethanol furnished the title compounds 3 . These compounds were characterized by CHN analyses, IR, mass and 1 H NMR spectral data. All the compounds were evaluated for their in vitro antibacterial activity against two Gram positive strains ( Bacillus subtilis and Staphylococcus aureus ) and two Gram negative strains ( Escherichia coli and Pseudomonas aeruginosa ), and their minimum inhibitory concentration (MIC) was determined.