Acute hypoxia and pulmonary vasoconstriction in humans: uncovering the mechanism of the pressor response

University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6021 This essay looks at the historical significance of an APS classic paper that is freely available online: Motley HL, Cournand A, Werko L, Himmelstein A, and Dresdale D. The influence of short periods of induced acute anoxia upon pulmonary artery pressures in man. Am J Physiol 150: 315–320, 1947 ( http://ajplegacy.physiology.org/cgi/reprint/150/2/315 ). Address for correspondence: A. P. Fishman, Office of Program Development, University of Pennsylvania School of Medicine, 1320 Blockley Hall, 423 Guardian Dr., Philadelphia, PA 19104-6021 (E-mail: alamin{at}mail.med.upenn.edu )