Effect of weight loss on muscle lipid content in morbidly obese subjects

Departments of Exercise and Sport Science, Surgery, and the Human Performance Laboratory and Diabetes/Obesity Center, East Carolina University, Greenville, North Carolina 27858 The purpose of this study was to test the hypothesis that weight loss results in a reduction in intramuscular lipid (IMCL) content that is concomitant with enhanced insulin action. Muscle biopsies were obtained from morbidly obese individuals [body mass index (BMI) 52.2 ± 2.5 kg/m 2 ; n = 6] before and after gastric bypass surgery, an intervention that improves insulin action. With intervention, there was a 47% reduction ( P