Three-Dimensional Reconstruction and Finite Element Modeling Analysis of the Rabbit Optic Nerve Head in Acute High Intraocular Pressure

To construct a three-dimensional (3D) rabbit optic nerve head (ONH) model by optical coherence tomography (OCT) images, demonstrate the effectiveness and validity of the model by comparison with changes in the ONH in vivo acute high intraocular pressure (IOP) of the living rabbit. Stress and deformation field analysis of the 3D rabbit ONH model was performed using the finite element method (FEM). Immediately after saline was perfused into the anterior chamber of the rabbit eye in an acute high IOP experiment, the same rabbit eye was scanned by OCT, the OCT had a scan speed of 27000 A scans per second with $3.0\times 3.0\times 2.3$ mm 3 (horizontal $\times$ vertical $\times$ axial) range. The changes of the in vivo ONH in OCT images were compared with the results of the FEM analysis, the morphological deformations were in accordance with the tendency predicted using FEM analysis.