GUANIDINE COMPOUNDS. II. PREPARATION OF MONO- AND N,N-DI-ALKYLGUANIDINES

1-Guanyl-3,5-dimethylpyrazole nitrate is superior to S-methylisothiouronium sulphate as a reagent for preparation of simple salts of mono- and N,N-di-alkylguanidines from cyclohexylamine, trans-2-aminocyclohexanol, pyrrolidine, and piperidine. S-Methylisothiouronium sulphate, however, gave a higher conversion in the case of dimethylamine. Cyanamide is not as useful a guanylating agent as those mentioned above. The paper chromatography of the mono- and N,N-di-alkylguanidines and the parent amines was studied using four solvent systems.