A CONVENIENT SYNTHESIS OF DL-ORNITHINE

A CONVENIENT SYNTHESIS OF DL-ORNITHINE

DL-Ornithine is readily prepared in a 68% yield by condensing 3-bromopropylphthalimide with ethyl acetamidocyanoacetate and by hydrolyzing the resulting 2-acetamido-2-carbethoxy-5-phthalimidovaleronitrile into DL-ornithine, isolated as the monohydrochloride. 3-Bromopropylphthalimide is obtained in a...

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Veröffentlicht in:Canadian journal of chemistry 1953-11, Vol.31 (11), p.1060-1063
1. Verfasser: Gaudry, Roger
Format: Artikel
Sprache:eng
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Zusammenfassung:DL-Ornithine is readily prepared in a 68% yield by condensing 3-bromopropylphthalimide with ethyl acetamidocyanoacetate and by hydrolyzing the resulting 2-acetamido-2-carbethoxy-5-phthalimidovaleronitrile into DL-ornithine, isolated as the monohydrochloride. 3-Bromopropylphthalimide is obtained in a 57% yield from 3-aminopropanol by reaction with phthalic anhydride, followed by phosphorus tribromide.
ISSN:0008-4042
1480-3291
DOI:10.1139/v53-139