F6 Does premanifest HD perform worse in arithmetic? Symbol digit and calculation tests confirm early cognitive impairment in preHD and correlate with brain MRI abnormalities

F6 Does premanifest HD perform worse in arithmetic? Symbol digit and calculation tests confirm early cognitive impairment in preHD and correlate with brain MRI abnormalities

ObjectivesWe aimed to identify markers of cognitive and structural brain abnormalities in premanifest Huntington’s disease subjects (preHD).Participants and methodsWe enrolled 29 preHD (13F/16 M, age 36.5 years, CAG range 37–48; UHDRS-TMS

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Veröffentlicht in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2016-09, Vol.87 (Suppl 1), p.A50-A50
Hauptverfasser: Castaldo, Anna, Nanetti, Lorenzo, Bachoud-Lévi, Anne-Catherine, Giavazzi, Maria, Contarino, Valeria, Nava, Simone, Mongelli, Alessia, Gellera, Cinzia, Grisoli, Marina, Bruzzone, Maria Grazia, Bella, Daniela Di, Ciammola, Andrea, Taroni, Franco, Mariotti, Caterina
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Sprache:eng
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Zusammenfassung:ObjectivesWe aimed to identify markers of cognitive and structural brain abnormalities in premanifest Huntington’s disease subjects (preHD).Participants and methodsWe enrolled 29 preHD (13F/16 M, age 36.5 years, CAG range 37–48; UHDRS-TMS
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp-2016-314597.141