Predictive value of integrated 18 F-FDG PET/MRI in the early response to nivolumab in patients with previously treated non-small cell lung cancer

The early response to treatment with immune-checkpoint inhibitors is difficult to evaluate. We determined whether changes in integrated [ F]-fluoro-2-deoxy-D-glucose positron emission tomography/MRI ( F-FDG PET/MRI) parameters after the first 2 weeks of antiprogrammed death-1 antibody nivolumab therapy could predict the response of patients with non-small cell lung cancer (NSCLC). Twenty-five patients with previously treated NSCLC were enrolled prospectively and underwent F-FDG PET/MRI before and at 2 weeks after nivolumab therapy. Changes in maximal standardized uptake value, total lesion glycolysis (ΔTLG) and apparent diffusion coefficient (ΔADC) between the two scans were calculated and evaluated for their associations with the clinical response to therapy. The disease control rate was 64%. Patients with non-progressive disease (non-PD) had significantly decreased TLG, increased ADC (ie, negative ΔADC ) and lower ΔTLG+ΔADC than patients with PD. Among the parameters tested, receiver operating characteristic curve analysis revealed that a cut-off value of 16.5 for ΔTLG+ΔADC had the highest accuracy (92%) for distinguishing between patients with non-PD and PD. A ΔTLG+ΔADC value