503 A Significance of Thrombocytosis as A Prognostic Factor in Korean Patients With Epithelial Ovarian Cancer

Background and Aims: We tried to determine the relevance of thrombocytosis as a role of independent prognostic factor among clinico-pathological variables in Korean patients with epithelial ovarian cancer. Methods: One hundred and eighty-three (183) patients with epithelial ovarian cancer had been surgically treated in Hanyang University Hospital between Jan. 1984 and Dec. 2002. Uni and Multivariate analyses were performed of 9 clinical variables including age, FIGO stage, histologic subtype, grade, volume of residual tumor, presence of ascites, pretreatment levels of hemoglobin, platelet and initial CA 125 level. Univariate and a multiple logistic regression analysis based on Cox-proportional hazard model was done to find the independent prognostic variables and Kaplan-Meier method for survival analysis. Results: in univariate analysis, FIGO stage (p = 0.015), the volume of residual tumor (p = 0.032), grade (p = 0.029), presence of ascites (p = 0.01) and thrombocytosis (platelet count > 400,000/mm3) (p = 0.013) were significant independent prognostic variables. Thrombocytosis was significant independent prognostic factor in early stage of disease (p = 0.041) and the volume of residual tumor (p = 0.004) remain in multivariate analysise. Conclusions: The volume of residual tumor were significantly independent prognostic factor in Korean patients with epithelial ovarian cancer. Thrombocytosis is a useful prognostic factor in early stage of disease.