THU0468 Osteoporosis and Osteocalcin Levels in Patients with Gout

BackgroundGout is a rheumatic disease characterized by the deposition of monosodium urate crystals in the joints and surrounding tissues. Gout is the most common inflammatory arthritis in men. It affects 1–2% of the adult population. Comorbid conditions and drugs used in gout are thought to increase the risk of osteoporosis but unlike some other forms of rheumatic diseases, gout is not believed to cause osteoporosis.ObjectivesIn our study, we aimed to investigate the osteoporosis and osteocalsin levels in patients with gout.Methods70 patients diagnosed with gout and 53 age-sex match controls were included in the study. Cardiovascular diseases, chronic renal disease, diabetes mellitus, hypertension, thyroid disease, bone disorders, eating disorders, gastrointestinal surgery or disease history, steroid use, alcohol use, patients with family history of osteoporotic fracture were excluded. The t and z scores from lumbar spine (L2-L4) and femur (neck, ward, trochanter, total) were determined by Dual energy X-ray absorptiometry (DEXA). Osteocalcin levels was measured by electrochemiluminescent immunoassay (ECLIA).ResultsOsteoporosis according to t- scores of lumbar vertebrae L2-L4 was found to be significantly higher in patients with gout compare to control group (p=0.02). There was no correlation between osteoporosis and the frequency of gout attacts, tophi and disease duration. Osteocalcin levels were detected to be significantly increased in the gout patients compare to control group (p=0.004). Vitamin D levels were similar in gout and control group (p=0.14). Alkaline phosphatase, parathyroid hormone levels were found to be significantly lower in control group compare to gout group (p=0.001).Table 1.Gout patients and control group resultsParameterGout (n=70)Control (n=53)pOsteoporosis , n (%)16 (22.9%)5 (9.4%)0.02*Osteopenia, n (%)35 (50%)23 (43.4%)NSOsteocalcin (ng/ml)26.6 (14.9–53.8)18 (14.2–25.2)0.004*Vitamin D (ng/ml)20.3 (13.2–25.6)16 (11–25)NSParathyroid hormone (pg/ml)57.9 (42–86)43.7 (33.8–55)0.001*Alkaline phosphatase (U/L)76 (63.2–92.5)62 (48–76.5)0.001*Values are presented as median (25–75 interquartile ranges. *P