Constitutive and variable components of gene expression profiles in pig liver

A comparative analysis of profiles of gene expression (PGEs) was carried out in the liver and kidneys of pigs. Groups of genes with constitutive and variable expression were recognized. It was found that the variable part of PGEs could be subdivided into groups whose genes demonstrated expression-level correlations from animal to animal. The dependence of the expression of such gene groups on their involvement in metabolic pathways and on exo- and endogenous regulating factors is discussed, as well as the role of the variable PGE portion in the variation of the results of studies performed in different laboratories with the same subjects.