Increase in radiosensitivity of cells after inhibition of their ability to repair after potentially lethal irradiation damage

This study presents new experimental data demonstrating the recovery of irradiated cells in a nutrition medium that is usually associated with proliferation retardation. The effect of such recovery on the radiosensitivity of diploid yeast cells of different strains after ionizing and UV irradiation was determined by a previously described method. Observed increase of radiosensitivity was shown to be much higher than expected after the inhibition of recovery after potentially lethal damage. The data show that the inhibition of cells ability to recover after potentially lethal damages after incubation of irradiated cells in a nonnutrition medium can in many cases be an indicator of suppression of the total cells’ ability to recover. Presented experimental data indicate that this rule is not universal.