Multicomponent Synthesis of 1,3-Bis[(alkylsulfanyl)methyl]-1,3,5-triazinan-2-ones

Previously unknown 5-alkyl-1,3-bis[(alkylsulfanyl)methyl]-1,3,5-triazinan-2-ones have been syn­thesized by three-component condensation of available N , N ′-bis[(alkylsulfanyl)methyl]ureas with formaldehyde and primary amines in ethanol in the presence of sodium hydroxide or triethylamine. A one-pot four-component procedure has been proposed for the synthesis of the title compounds via successive thiomethylation of urea with a mixture of formaldehyde and alkanethiol and cycloaminomethylation of intermediate N , N ′-bis[(alkyl­sulfanyl)methyl]ureas with formaldehyde and alkylamine.