Design, Synthesis, and In Vitro Cytotoxic Activity of Certain 2-[3-Phenyl-4-(pyrimidin-4-yl)-1H-pyrazol1-yl]acetamide Derivatives

With a view to finding new anticancer agents, different aryloxy groups were attached to C 2 of the pyrimidine ring in 2-[3-phenyl-4-(pyrimidin-4-yl)-1 H -pyrazol-1-yl]acetamide in five steps using methyl 3-methoxy-5-methylbenzoate as the key intermediate product. The anticancer activity of the synthesized compounds was tested on 60 cancer cell lines at 10 µM. One compound showed an appreciable cancer cell growth inhibition (about 20%) against eight cancer cell lines (HOP-92, NCI-H226, 79SNB-75, A498, SN12C, UO-31, T-47D, and MDA-MB-468).