Specific features of the reduction of disubstituted amide derivatives of p-tert-butylcalix[4]arene

Regardless of the reducing agent, the reduction at 25°C and higher of the amide groups in a large number of p-tert -butylcalix[4]arene derivatives containing amide fragments with different substituents on the nitrogen atoms was accompanied by hydrogenolysis of the C-N bond with formation of the corresponding O -(2-hydroxyethyl) calixarenes and by partial cleavage of the ether bond between the calixarene framework and the substituent to give compounds with a lower degree of substitution.