Synthesis of 1,2,4-triazole-3-thiols and their S-substituted derivatives

Synthesis of 1,2,4-triazole-3-thiols and their S-substituted derivatives

New 1,2,4-triazole-3-thiols were synthesized by reactions of the corresponding carboxylic acid hydrazides with isothiocyanates and subsequent cyclization of intermediate 1,4-substituted thiosemicarbazides. Alkylation of 1,2,4-triazole-3-thiols with benzyl chlorides and bromacetophenones gave only S-...

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Veröffentlicht in:Russian journal of organic chemistry 2010-04, Vol.46 (4), p.551-555
Hauptverfasser: Kochikyan, T. V, Samvelyan, M. A, Arutyunyan, V. S, Avetisyan, A. A, Tamazyan, R. A, Aivazyan, A. G
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Organic Chemistry
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Zusammenfassung:New 1,2,4-triazole-3-thiols were synthesized by reactions of the corresponding carboxylic acid hydrazides with isothiocyanates and subsequent cyclization of intermediate 1,4-substituted thiosemicarbazides. Alkylation of 1,2,4-triazole-3-thiols with benzyl chlorides and bromacetophenones gave only S-substituted derivatives.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428010040184