Synthesis of analogs of ecdysteroids containing an isoxaline ring in the side chain

Synthesis of analogs of ecdysteroids containing an isoxaline ring in the side chain

Starting with poststerone a synthesis was performed of ecdysteroid analogs containing an isoxaline ring in the side chain. The key stages of the route to the target products were Normant reaction and the subsequent 1,3-dipolar cycloaddition of nitrile oxides to 20-hydroxy-20-vinylsteroids.

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Veröffentlicht in:Russian journal of organic chemistry 2008-11, Vol.44 (11), p.1590-1597
Hauptverfasser: Litvinovskaya, R. P., Drach, S. V., Zhilitskaya, G. A., Khripach, V. A.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Organic Chemistry
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Zusammenfassung:Starting with poststerone a synthesis was performed of ecdysteroid analogs containing an isoxaline ring in the side chain. The key stages of the route to the target products were Normant reaction and the subsequent 1,3-dipolar cycloaddition of nitrile oxides to 20-hydroxy-20-vinylsteroids.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428008110043