Polymeric hydrogels with memory effect for immobilization of binary drug combinations

Hydrogels with memory effect (imprinted hydrogels) with respect to a combination of cefotaxime and diclofenac were synthesized from 2-hydroxyethyl methacrylate and functional monomers (acrylic acid and N,N -dimethylacrylamide). The hydrogels obtained show increased ability to sorb cefotaxime and especially diclofenac. Prolonged release of cefotaxime was revealed, becoming more pronounced with an increase in the cefotaxime concentration in the solution from which it is sorbed with the hydrogel. The effect of selective sorption of diclofenac with imprinted hydrogels from the diclofenac-cefotaxime drug combination was discovered.