Synthesis, isolation, and purification of benzylpenicillin β-diethylaminoethyl ester hydroiodide

Processes of synthesis, isolation, and purification of benzylpenicillin β-diethylaminoethyl ester hydroiodide were studied. The optimal conditions of benzylpenicillin esterification with chloroethyldiethylamine in dimetylformamide and acetonitrile were found. Processes for isolation of the target pr...

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Veröffentlicht in:	Russian journal of applied chemistry 2010-07, Vol.83 (7), p.1230-1237
Hauptverfasser:	Savel’ev, E. A., Volkova, I. M., Kovalevskaya, A. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Chemistry and Materials Science Chemistry/Food Science Industrial Chemistry/Chemical Engineering Organic Synthesis and Industrial Organic Chemistry
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Processes of synthesis, isolation, and purification of benzylpenicillin β-diethylaminoethyl ester hydroiodide were studied. The optimal conditions of benzylpenicillin esterification with chloroethyldiethylamine in dimetylformamide and acetonitrile were found. Processes for isolation of the target product were developed and its physicochemical properties were studied. Product stabilization conditions providing a stable pH value in solutions of benzylpenicillin β-diethylaminoethyl ester hydroiodide were found.
ISSN:	1070-4272 1608-3296
DOI:	10.1134/S1070427210070128