Synthesis and Antinociceptive Activity of Substituted 5-(Het)aryl-3-(4-methylbenzoyl)hydrazono-3H-furan-2-ones

The method was proposed for the synthesis of new substituted 5-(het)aryl-3-(4-methylbenzoyl)hydrazono-3 H -furan-2-ones by intramolecular cyclization of 2-[2-(4-methylbenzoyl)hydrazono]-4-oxobut-2-enoic acids in the presence of propionic anhydride. The antinociceptive activity of the obtained compou...

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Veröffentlicht in:	Russian journal of general chemistry 2021-12, Vol.91 (12), p.2469-2474
Hauptverfasser:	Lipin, D. V., Denisova, E. I., Devyatkin, I. О., Okoneshnikova, Е. А., Shipilovskikh, D. A., Makhmudov, R. R., Igidov, N. M., Shipilovskikh, S. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Chemistry and Materials Science Chemistry/Food Science
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Beschreibung
Zusammenfassung:	The method was proposed for the synthesis of new substituted 5-(het)aryl-3-(4-methylbenzoyl)hydrazono-3 H -furan-2-ones by intramolecular cyclization of 2-[2-(4-methylbenzoyl)hydrazono]-4-oxobut-2-enoic acids in the presence of propionic anhydride. The antinociceptive activity of the obtained compounds was studied.
ISSN:	1070-3632 1608-3350
DOI:	10.1134/S1070363221120161