Special features of preparing benzoaza-12-crown-4 by condensation of o-aminophenol with triethylene glycol dichloride

Preparative method of benzoaza-12-crown-4 preparation via condensation of o -aminophenol with trietylene glycol dichloride using sodium hydroxide as the template agent has been studied at elevated temperature in 2-propanol and n -butanol. Kinetics of the reaction mixture composition change in the course of the process has been investigated by GLC. Performing the reaction in 2-propanol leads to a higher yield of benzoaza-12-crown-4.