Synthesis and properties of 2-substituted 5-chloro-1,3-oxazole-4-carboxamides

Synthesis and properties of 2-substituted 5-chloro-1,3-oxazole-4-carboxamides

Chlorination of 2-aryl-5-benzylsulfanyl-1,3-oxazole-4-carbonitrile in aqueous acetic acid at 50–60°C afforded new 2-aryl-5-chloro-1,3-oxazole-4-carboxamides. The reactivity of the chlorine atom with respect to the N-, O-, and S-nucleophiles was investigated.

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Veröffentlicht in:Russian journal of general chemistry 2014-06, Vol.84 (6), p.1186-1189
Hauptverfasser: Kornienko, A. N., Pil’o, S. G., Prokopenko, V. M., Brovarets, V. S.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Zusammenfassung:Chlorination of 2-aryl-5-benzylsulfanyl-1,3-oxazole-4-carbonitrile in aqueous acetic acid at 50–60°C afforded new 2-aryl-5-chloro-1,3-oxazole-4-carboxamides. The reactivity of the chlorine atom with respect to the N-, O-, and S-nucleophiles was investigated.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363214060206