Cryosynthesis of nanosized drug substances

The specific features of cryochemical technology for producton of new nanosized modifications of drug substances are observed. The method is based on transformation of the initial substance in gas phase and followed by the organization of molecular flow to the cooled surfaces. The results of study o...

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Veröffentlicht in:Russian journal of general chemistry 2014-05, Vol.84 (5), p.1010-1017
Hauptverfasser: Morozov, Yu. N., Utekhina, A. Yu, Shabatin, V. P., Chernyshev, V. V., Sergeev, G. B.
Format: Artikel
Sprache:eng
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Zusammenfassung:The specific features of cryochemical technology for producton of new nanosized modifications of drug substances are observed. The method is based on transformation of the initial substance in gas phase and followed by the organization of molecular flow to the cooled surfaces. The results of study of physicochemical properties of nanosized drug substances obtained for different applications are presented: cardiological carvedilol, cytostatic imatinibe mesilate, steroid hormone Δ 5 androstendiol-3β,17β, psychoactive phenasepam. On example of the last compound the results of biological tests are presented.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363214050387