Design of pharmaceutical cocrystals for drug solubility improvement

The new technology of enhancement of the solubility of poorly soluble drug substances is based on the synthesis and application of cocrystal pharmaceutical systems. The solubility and bioavailability of such systems are several orders of magnitude higher than those for the individual compounds and m...

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Veröffentlicht in:	Russian journal of general chemistry 2014-02, Vol.84 (2), p.407-414
Hauptverfasser:	Perlovich, G. L., Manin, A. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Chemistry and Materials Science Chemistry/Food Science Supplement: Rossiiskii Khimicheskii Zhurnal-Zhurnal Rossiiskogo Khimicheskogo Obshchestva im. D.I. Mendeleeva (Russian Chemistry Journal)
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Beschreibung
Zusammenfassung:	The new technology of enhancement of the solubility of poorly soluble drug substances is based on the synthesis and application of cocrystal pharmaceutical systems. The solubility and bioavailability of such systems are several orders of magnitude higher than those for the individual compounds and much higher than the respective parameters attainable by other technologies.
ISSN:	1070-3632 1608-3350
DOI:	10.1134/S107036321402042X