Chemical modification of tetraene macrolide antibiotic nystatin A1 with organophosphorus alcohols

Esterification of tetraene macrolide antibiotic nystatin A 1 with organophosphorus alcohols has been studied; formation of the corresponding organophosphorus esters of the antibiotic has been confirmed. Physicochemical, spectral, and biological properties of the prepared esters have been studied. Th...

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Veröffentlicht in:	Russian journal of general chemistry 2014-02, Vol.84 (2), p.295-297
Hauptverfasser:	Belakhov, V. V., Shenin, Yu. D., Dogadina, A. V., Aleshunina, D. V., Ionin, B. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Chemistry and Materials Science Chemistry/Food Science
Online-Zugang:	Volltext
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Zusammenfassung:	Esterification of tetraene macrolide antibiotic nystatin A 1 with organophosphorus alcohols has been studied; formation of the corresponding organophosphorus esters of the antibiotic has been confirmed. Physicochemical, spectral, and biological properties of the prepared esters have been studied. The esterification products have revealed high antifungal activity towards the Candida yeast fungi.
ISSN:	1070-3632 1608-3350
DOI:	10.1134/S1070363214020248