Novel metabolically stable and functionally active mimetic of spermidine

Earlier unknown 1,8-diamino-3-methyl-4-azanonane (γ-MeSpd) was synthesized. The analogue was a substrate of neither spermine/spermidine N 1 -acetyltransferase nor spermine synthase, but was capable to support the growth of DU145 cells having depleted polyamine pools. Such a combination of γ-MeSpd pr...

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Veröffentlicht in:	Russian journal of bioorganic chemistry 2011-03, Vol.37 (2), p.225-230
Hauptverfasser:	Khomutov, M. A., Hyvönen, M. T., Simonian, A. R., Vepsäläinen, J., Alhonen, L., Kochetkov, S. N., Keinänen, T. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Life Sciences Organic Chemistry
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Earlier unknown 1,8-diamino-3-methyl-4-azanonane (γ-MeSpd) was synthesized. The analogue was a substrate of neither spermine/spermidine N 1 -acetyltransferase nor spermine synthase, but was capable to support the growth of DU145 cells having depleted polyamine pools. Such a combination of γ-MeSpd properties discloses novel opportunities to study cellular functions of catabolically unstable and easily interconvertible spermine and spermidine.
ISSN:	1068-1620 1608-330X
DOI:	10.1134/S1068162011020075