Myelopeptide MP-5 and fluorescent derivatives: Synthesis and biological activity
The Val-Val-Tyr-Pro-Asp bone marrow peptide (MP-5) and its analogue (MP-5-Lys) were synthesized. Fluorescent derivatives, Ftc-MP-5 and MP-5-Lys(Ftc), were prepared. The iological activity of MP-5 and MP-5-Lys was studied in vitro and in vivo. The MP-5 peptide caused 60–84% inhibition of growth of th...
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| Veröffentlicht in: | Russian journal of bioorganic chemistry 2008-07, Vol.34 (4), p.404-408 |
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| container_title | Russian journal of bioorganic chemistry |
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| creator | Fonina, L. A. Az’muko, A. A. Kalikhevich, V. N. Lewit, M. L. Ardemasova, Z. A. Gur’yanov, S. A. Belevskaya, R. G. Efremov, M. A. Treshchalina, E. M. Mikhailova, A. A. |
| description | The Val-Val-Tyr-Pro-Asp bone marrow peptide (MP-5) and its analogue (MP-5-Lys) were synthesized. Fluorescent derivatives, Ftc-MP-5 and MP-5-Lys(Ftc), were prepared. The iological activity of MP-5 and MP-5-Lys was studied in vitro and in vivo. The MP-5 peptide caused 60–84% inhibition of growth of the following mouse cancers: lymphatic leukemia P388, melanoma B-16, and cervical carcinoma CUC-5. These peptides also restored functional activity of T-lymphocytes that was inhibited by metabolic products of the HL-60 leukemic cell line. MP-5-Lys(Ftc) was shown to preserve the functional properties of MP-5 towards T-lymphocytes, but Ftc-MP-5 was practically inactive. |
| doi_str_mv | 10.1134/S106816200804002X |
| format | Article |
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The MP-5 peptide caused 60–84% inhibition of growth of the following mouse cancers: lymphatic leukemia P388, melanoma B-16, and cervical carcinoma CUC-5. These peptides also restored functional activity of T-lymphocytes that was inhibited by metabolic products of the HL-60 leukemic cell line. MP-5-Lys(Ftc) was shown to preserve the functional properties of MP-5 towards T-lymphocytes, but Ftc-MP-5 was practically inactive.</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Life Sciences</subject><subject>Organic Chemistry</subject><subject>Review Articles</subject><issn>1068-1620</issn><issn>1608-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp9kN1Kw0AQhRdRsFYfwLu8QHRmf9Ktd1L8A4uFKvQubDazdUtMym5ayNu7td4JXs2B853DcBi7RrhBFPJ2iVBoLDiABgnAVydshAXoXAhYnSad7Pzgn7OLGDcACKD0iC3mAzXdlra9rymbL3KVmbbOXLPrAkVLbZ_VFPze9H5P8S5bDm3_SdHHH6zyXdOtvTVNZmwifD9csjNnmkhXv3fMPh4f3mfP-evb08vs_jW3XOs-V7WwQk9BaC6ckLJQVk7IOHS8kBWHaqIsOZEUytopqQAdkJhiVRVacCnGDI-9NnQxBnLlNvgvE4YSoTxMUv6ZJGX4MRMT264plJtuF9r05j-hb4QbYxE</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Fonina, L. 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| subjects | Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Life Sciences Organic Chemistry Review Articles |
| title | Myelopeptide MP-5 and fluorescent derivatives: Synthesis and biological activity |
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