Myelopeptide MP-5 and fluorescent derivatives: Synthesis and biological activity

Myelopeptide MP-5 and fluorescent derivatives: Synthesis and biological activity

The Val-Val-Tyr-Pro-Asp bone marrow peptide (MP-5) and its analogue (MP-5-Lys) were synthesized. Fluorescent derivatives, Ftc-MP-5 and MP-5-Lys(Ftc), were prepared. The iological activity of MP-5 and MP-5-Lys was studied in vitro and in vivo. The MP-5 peptide caused 60–84% inhibition of growth of th...

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Veröffentlicht in:Russian journal of bioorganic chemistry 2008-07, Vol.34 (4), p.404-408
Hauptverfasser: Fonina, L. A., Az’muko, A. A., Kalikhevich, V. N., Lewit, M. L., Ardemasova, Z. A., Gur’yanov, S. A., Belevskaya, R. G., Efremov, M. A., Treshchalina, E. M., Mikhailova, A. A.
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Life Sciences
Organic Chemistry
Review Articles
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Zusammenfassung:The Val-Val-Tyr-Pro-Asp bone marrow peptide (MP-5) and its analogue (MP-5-Lys) were synthesized. Fluorescent derivatives, Ftc-MP-5 and MP-5-Lys(Ftc), were prepared. The iological activity of MP-5 and MP-5-Lys was studied in vitro and in vivo. The MP-5 peptide caused 60–84% inhibition of growth of the following mouse cancers: lymphatic leukemia P388, melanoma B-16, and cervical carcinoma CUC-5. These peptides also restored functional activity of T-lymphocytes that was inhibited by metabolic products of the HL-60 leukemic cell line. MP-5-Lys(Ftc) was shown to preserve the functional properties of MP-5 towards T-lymphocytes, but Ftc-MP-5 was practically inactive.
ISSN:1068-1620
1608-330X
DOI:10.1134/S106816200804002X