Polymethylene derivatives of nucleic bases with ω-functional groups: VI. [8-(2-oxocyclohexyl)-9-oxooctyl]pyrimidines as potential inhibitors of pyrimidine phosphorylases

Polymethylene derivatives of nucleic bases with ω-functional groups: VI. [8-(2-oxocyclohexyl)-9-oxooctyl]pyrimidines as potential inhibitors of pyrimidine phosphorylases

New polymethylene derivatives of nucleic bases with β-diketo function in ω-position were prepared by alkylation of uracil, thymine, and cytosine. Their physicochemical properties and effect on the E. coli uridine and thimidine phosphorylases were studied.

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Veröffentlicht in:Russian journal of bioorganic chemistry 2008, Vol.34 (1), p.67-73
Hauptverfasser: Komissarov, V. V, Panova, N. G, Kritzyn, A. M
Format: Artikel
Sprache:eng
Schlagworte:
alkylation
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Life Sciences
nucleosides
Organic Chemistry
polymethylene analogues
pyrimidine phosphorylases
β-diketones
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Zusammenfassung:New polymethylene derivatives of nucleic bases with β-diketo function in ω-position were prepared by alkylation of uracil, thymine, and cytosine. Their physicochemical properties and effect on the E. coli uridine and thimidine phosphorylases were studied.
ISSN:1068-1620
1608-330X
1573-9163
DOI:10.1134/S1068162008010093